For improving the soft soil foundation of domestic coastal and inland areas and guarantee the stability of over-water buildings, the sand compaction pile of artificial processing methods of soft soil foundation is widely used in recent years. The sand compaction pile by KS-REACT’s method is that under the action of vibration, the sand pile is expanded in diameter through controlling the air pressure inside the pipe. The application of this method to the soft foundation treatment in the Hong Kong-Zhuhai-Macao bridge resulted in perfect pile quality, fast foundation reinforcement, and low sand loss rate. The measures taken for dealing with the problems in construction provide valuable reference for the compaction pile constructions in the future.