Based on the wave model test for the section of vertical breakwater with culvert under the action of irregular wave, we study the main factors such as the wave steepness (H/L), relative water depth(d/H), relative plate wide(B/L), relative depth of the culvert into water(t/d) and period affecting the wave uplift pressure intensity on the top of culvert of vertical breakwater with culvert and corresponding variation law. By analyzing the experiment data, we revise and verify the GuoDa formula and obtain the empirical formula for the maximum relative uplift pressure intensity on top of the culvert.