In order to better understand the relationship between port logistics and regional economy and develop a proper interactive development strategy, the paper selects the data of the port logistics and regional economy of Nantong in 1990-2011, and makes an empirical research and analysis on the interaction with Granger causality. The results show that there is a one-way causality between port logistics and regional economy of Nantong.The promoting effect of port logistics to regional economy is more than that to port logistics from regional economy.