In view of the suggestions from the newly issued Design and Construction Code for Open Type Wharf on Piles that slab effect should be ignored for calculating internal force of longitudinal beams and cross beams in spatial structure calculation for beam-slab wharf on high piles, we take a structural section of a high-pile wharf project in Zhanjiang as an engineering example, and establish several spatial structure calculation models by ANSYS to study two modeling methods of ignoring slab effect and analyze the slab stiffness effect in spatial structure calculation for beam-slab wharf on high piles by comparing the calculation results of various models. The comparison results show that setting the elastic modulus of slab to the minimum value is a convenient and feasible method of ignoring slab effect in spatial structure calculation for beam-slab wharf on high piles, which provide a reference for high-pile wharf designers.