Based on the case of Naxigou port in Three Gorge reservoir, taking advantages of the finitedynamic simulation method, we establish the collision model between ship and frame-pier wharf by non-linear analysis software ANSYS/LS-DYNA. In order to simulate the interaction among the ship, the frame-pier wharf and the rubber fender more accurately, we take the cushioning effect and energy absorption of rubber fender into consideration in this model. The influence of various factors are also analyzed.