To discuss port logistics base development strategy and the best layout program in southwest China, we analyze domestic and international port logistics development stage and prerequisites, and put forward the mature condition and problems in southwest port logistics, and investigate basic problems to be solved in the construction and development of inland port logistics parks, together with the development mode, operation mode, development style, and site selection principle, etc. Taking Chongqing Guoyuan port logistics park, the largest port logistics park in China, as an example, we carry out an analysis based on the theory presented and achieve the development strategy and proper layout plan for the inland port logistics park.