In the research of soil-pile interaction with finite element method, the results are consequently varying when we adopt different interface elements. Conducting finite element analysis of single pile separately with Desai element and Goodman element, we study the interface element’s impact on the feature of interface mechanic behavior between soil and pile, and the stress and displacement behavior of the single pile. It is concluded that the differences of mechanical traits of contact interface and the differences of the stress and displacement are minor when the top load of pile is relatively low. On the contrary, when the top load of pile is comparatively high, the differences of two kinds of element are apparent in the following aspects: when adopting Goodman element the subside of the pile block is smaller than that of Desai element, the shear stress on the contact interface is bigger, and the axial force descends quickly along the pile body. The resistance and subside of the pile tip are smaller while the vertical allowable load capacity of single pile is greater.