To counter the problems and deficiencies existing in the blow-fill-construct craft of dredged materials in the Yangtze estuary, we carry out an experimental study on key techniques of comprehensive utilization of dredged materials. The results show that problems concerning the blow-fill-construct craft, specific soil blown transmission equipment, machines and tools, dredging sediment transport monitoring (Neutron tracer and ADCP measurement of sediment) and separation of water-sediment have been solved in general in the deep-water channel regulation project of the Yangtze estuary, and it has laid a technological basis for the improvement of comprehensive utilization of dredged soils in China.