Based on the analysis of the mutual development of port and regional economy, this paper constructs two evaluation models base on DEA, one of which is a horizontal model to evaluate the port and regional economy and the other is a time-dynamic longitudinal model to evaluate the relationships between them.The horizontal model results show that the port and regional economy of Qingdao are dual-valid, and the regional economy of Weihai is valid but port of it is not. The port and regional economy of Yantai and Rizhao are invalid.It means that the port and economic development of each region in Shandong province is uneven, and there are great differences among regions. Results from the longitudinal models indicate that from 2000 to 2009, the port and regional economy failed to achieve the effective coordination. Finally, this paper proposes some targeted strategic initiatives which can promote the coordinated development of port and regional economy.