High pile structure is a kind of structure widely used in port and coast.Its dynamic response under wave action is the key factor to ensure the stable operation of the wharf.The software ABAQUS is used to build a three-dimensional wharf model and a wave flume with STAR-CCM+.The k-ε turbulence model and volume of fluid (VOF) motion interface tracking method are used to simulate waves,and the simulation of bidirectional coupling between wharf pile groups and waves is realized.Since the ratio of pile spacing to pile diameter is greater than 4,the interaction between piles does not need to be considered,and the error of the comparison model test is less than 5%,which can meet the requirements.The results show that the maximum force and displacement of the wharf pile groups under wave heights of 0.3 m,0.4 m,and 0.5 m can meet the code requirements.The displacement at the top of the pile is the largest,which is 0.66 mm.The maximum stress occurs at the bottom of the front row of piles in the pile group,which is 152.4 kPa.The concrete in the pile bottom area is prone to instability and failure,and special attention should be paid in practical engineering.