The condition of waterway regulation in Dongjiang River is complicated，so the model study can provide important technical support and basis for the feasibility of waterway regulation technical scheme.Through the analysis of riverbed evolution，flow condition and channel regulation model，the rationality and regulation effect of different regulation schemes are studied，and the recommended channel regulation schemes are put forward.The results show that the water depth of Lanpai Shoal，Hengling Shoal and downstream section of Guanyinge Shoal is more than 2.5 m.The water depth of Menghutiaoqiang shoal and upstream section of Guanyinge trough is less than 2.5 m.The water depth along the channel is more than 2.5 m under the designed flow，and the water level reduction value along the channel is between 0.77 and 2.26 m.After local sand mining，the water level of the upper reaches of each shoal section is reduced to different degrees，and the water depth of the trough cannot meet the requirement of 2.5 m after local sand mining.The reach is sand mining，and the influence of sand mining on channel regulation scheme is very sensitive.The recommended channel regulation scheme is adopted and the sand mining behavior is strictly controlled for the channel regulation downstream of Likou Dam in Dongjiang River.