In view of the complex layout of third-line ship lock caused by the numerous buildings around the Qingyuan Hub,this paper identifies a layout scheme by comparing and analyzing the lock location options,structural and space reservation options and by using numerical simulation methods.The scheme includes location on the left bank,double-line ship lock with mutual filling and emptying and structural reservation.Meanwhile,the scheme extends the length of the upstream right permeable diversion dike to 350 m to ensure a reasonable layout.It proposes that the layout of the ship lock should be considered from the perspective of navigable flow conditions,interrelationship with existing buildings in the hub,influence on the structural safety and normal operation of the built buildings,navigation during the construction period,land acquisition and demolition,construction investment,etc.,which is an important guiding significance for the selection of the layout of the ship lock in the case of many surrounding buildings and environmental constraints.