In recent years，the practice of the Yangtze River channel regulation project has proved that permeable frames can well promote siltation and have thus gradually become an indispensable engineering component in this channel regulation project. The 6-meter-deep channel regulation project in the Wuhan to Anqing section of the Yangtze River trunk line has an intensive demand for frame prefabrication. Moreover，the prefabrication progress of permeable frames is far behind schedule due to the abnormal drop in water level at the end of 2019 and COVID-19 at the beginning of 2020. For the above reasons，this paper replaces the integral molds with assembled molds for prefabrication and conducts a comparative analysis from three aspects，namely，the finished product quality of prefabricated components，the demolding time of components，and the construction cost. It further presents a permeable frame prefabrication process with high quality，low cost，and high efficiency. In this way，the paper also shortens the construction period of subsequent throwing operations on water and minimizes the impact of the construction period on the environment.