Aiming at the problems of fine particles，loose structure，large specific surface area and strong water holding capacity of extracellular polymer substances (EPS) on the surface and inside of dredged slurry，which makes it difficult to separate water from the dredged slurry，Fenton oxidation-compound coagulant method is used to carry out the rapid slurry and water separation test of dredged slurry.With the goal of maximizing the slurry volume reduction rate，the orthogonal test and response surface method are used to optimize the process conditions，and the change of EPS concentration is analyzed.The results show that the main factor affecting Fenton oxidation effect is chemical agent dosage.Under the same cost condition，the slurry and water separation effect after Fenton oxidation-polyaluminum chloride treatment is the best.The order of the factors influencing slurry and water separation effect determined by the response surface method is coagulant additives type＞stirring speed＞coagulant additives dosage.Under the conditions of this experiment，the optimal process conditions are that the polyacrylamide dosage is 0.255 g/L and the stirring speed is 125 r/min.After Fenton oxidation-composite coagulation，the content of positively charged protein in EPS increases significantly，which can neutralize the negative charge of slurry and realize the rapid slurry and water separation of dredged slurry.The research results have theoretical significance for the practice of rapid slurry and water separation engineering of dredged slurry.