The main body of the new fully prefabricated high-piled wharf structure adopts modular design and is composed of new prefabricated components such as slot beam, bottomless π beam, the structure is novel, the components have large size and weight, high difficulty in installation and positioning, there is no precedent for construction.Taking the wharf engineering in Xuwei Port area of Lianyungang Port as an example, this paper analyzes the application advantages of the new high-piled wharf structure, and proposes technical measures such as new component prefabrication, precise positioning and installation, cavity node construction to solve the construction difficulties of the new wharf structure.The engineering practice is proved that the construction technical measures are advanced, safe and efficient, which can provide references for similar projects.