For the engineering geological environment in deep sea，a wave-current flume test scheme is designed for pile-supported wharf（PSW），and the experimental investigation on the dynamic response of PSW under wave-current action is carried out. The test really reproduces the operating condition of PSW，and the internal response difference of PSW is discussed，and the pore pressure and acceleration in the free field and soil layer around piles are analyzed. The results show that：1）The responses of each pile in PSW are obviously different，and hydrodynamic pressure on pile decreases gradually along the wave-current direction. The bending moment on the front pile is greater than that on the rear pile，and the bending moment on the middle pile is larger than that on the bilateral pile. 2）The displacement and acceleration of deck change periodically，and the torsion decreases with wave-current action. 3）The acceleration and pore pressure of soil layer gradually decrease with the wave-current propagation and increase of the burial depth，the pile group increases acceleration of soil layer and decreases its pore pressure. 4）In the design of PSW，the strength of middle pile should be appropriately increased and the reinforcement of surface seabed soil should be emphasized. The above research can provide a reference for the design and maintenance of PSW.