The dredging pipe is an important part of medium transportation in dredging engineering，and its friction resistance is one of the decisive factors for dredging distance and performance. Based on Sanjiasha south channel project with the fine silt soil，we carry out the field test and comparative analysis of the transportation resistance under different pipe combinations with 2m-rubber pipe and 12m-steel pipe for the dredging pipe. The results show that the pressure loss increases with the increase of transport velocity and concentration；The friction resistance of the steel pipe combination is the smallest，followed by the “4 steel pipe + 1 rubber pipe” combination，and the “1 steel pipe + 1 rubber pipe” combination has the largest friction resistance，which increases by about 6% compared with the steel pipe combination. The research result provides a guidance for the layout of dredging pipes on the project site.