After the Three Gorges became a reservoir，the river section from the Wujiang River Estuary to Baitao at Fuling became a perennial reservoir area at the tail of the Three Gorges reservoir，and the navigation conditions were greatly improved. The increase of the large vessels beyond the channel standard entering the Wujaing River highlighted the navigation risks.，Wujiang River beyond the channel standard is increasing，Wujiang River highlighted the navigation safety hazards. This paper probes into the navigation conditions for large ships with a length of 130 m when the water level of Qingxichang is over 160 m. The research results show that when the water level of Qingxi chang is 160 ~ 175 m and the flow from Wulong of Wujiang River is less than 2 000 m3/s，the navigation depth，width and bending radius of the research channel meet the navigation scale of large ships，but Sanmenzi，Longchuantuo，Xiaoxikou and Xinbengzi are restricted channels，Chongqing-Huaihua railway bridge and Sanmenzi are the river sections where boat meeting is prohibited，and the buildings across the river meet the dimension of navigation clearance of large ships. The navigation safety guarantee measures such as adjusting navigation aids，setting anti-collision facilities and safety warning signs in the bridge are put forward.