Regulation of the Danxikou rapids is a key project for the regulation of the Qujiang channel. The rising water level of Caojie Hydropower Station after impoundment and flood scouring lead to the development of the left branch of the river island and the collapse of the bank slope，consequently seriously endangering the stability of the navigation channel along the right bank and the property safety of residents on the left bank. This paper proposes building a revetment，enclosing the branch，flipping，and consolidating the beach as regulation measures and puts forward four regulation layout schemes. It calculates the multi-level flow of each regulation layout scheme with a two-dimensional numerical flow model and the maximum scouring depth formula. Then，it provides an optimal recommended regulation scheme through a comprehensive comparison according to the indexes of flow velocity，flow direction，and scouring depth. Specifically，the straight slope revetment prevents the continuous collapse of the left bank of Danxikou，the closure dam prevents the left branch from further deepening and widening，and the fish mouth revetment set at the head of the river island reduces scouring. The research results can provide a scientific basis for the design of the channel regulation project for the Danxikou section of the Qujiang River.