To study the influence of different construction schemes on the landing trestle of the pipeline，we combine with the actual engineering case of 40 million t/a refinery integration project，compare the two schemes of the upper structure including the pre-stressed concrete box girder structure and the large-span steel pipe tie-bar arch bridge + prefabricated small box girder structure，carry out the comprehensive consideration from the aspects of economy，the quantity of work，the structural durability，and the late maintenance，and propose the recommended scheme and key points of construction technology. The results show that generally it is convenient to use the pre-stressed concrete box girder structure for construction，and the number of pile foundations is more and safer. Moreover，this structure has a good self-corrosion protection effect and less maintenance in the later period. Considering comprehensively，when the product pipeline needs to land on the trestle，the pre-stressed concrete box girder structure should be preferred for the upper structure design of the trestle scheme. When designing the structure of the pre-stressed concrete box girder，it is necessary to reasonably control the pre-stress tension time，accurately analyze the stress characteristics of the structure and adopt appropriate pre-stress technology to ensure the suitability of construction work and the actual environment.