Shantou Port is the main coastal port in China and the only main port in the eastern part of Guangdong Province. By analyzing the current situation of Shantou Port and the development of hinterland economy and industry，the significance of inland port layout of Shantou Port is put forward. On this basis，19 prefecture-level cities in Guangdong，Fujian，Jiangxi and Hunan as the candidate cities for the location of the inland port of Shantou Port are selected，and a multi-level index system of the candidate cities is further constructed，which involves three elements of geographical transportation，economic basis and cost factors. The location of inland port is discussed by analytic hierarchy process，and some suggestions for site selection and development are put forward.