In the design of high-pile wharf，selection and arrangement of pile foundation impact on structure scheme significantly.For the structural design of high-piled beam-slab wharf in a project，we analyze the influence factors，such as hydrogeological conditions，designing load，etc.On the premise of security and reliability of the structure，we propose a recommended structure scheme by comparing two different selections and arrangements of pile foundation，and empirically summarize the construction points of recommended structure scheme according to the actual situation.