The features of large scale waterway regulation projects include long construction river sections,huge construction quantities,and excessive construction procedures.The construction water area has large navigable density and many kinds of ships.Safety control of construction and ship navigation is challenging due to dense traffic flow and various ship types.Based on the typical large scale waterway regulation projects located respectively at lower,middle,and upper reaches of the Yangtze River,aiming at the techniques of risk control and safety guarantee throughout the construction process,we apply the combined research methods of theoretical analysis,numerical simulation,field testing,and system development to improve risk identification and assessment accuracy,establish risk prediction model of navigation and production safety,study techniques of safety guarantee and control considering all aspects,processes,as well as factors,and develop integrated safety information platform of construction area.The results can provide a theoretical and technical guideline for ensuring safety control of construction and ship navigation in large scale waterway regulation projects.