To meet the requirement of 6 m waterway from Wuhan to Anqing in the period of the 13th Five-Year Plan, we study the regulation measures for the 6 m deep waterway of Liyushan, Wu’an section under the restriction of multiple factors. Analyzing the current condition of the 6 m deep waterway, we clarify the problems of the waterway and probe into the shoal regulation idea and measures simply under technical factors. To counter the contradiction between the engineering measures simply under technical factors and watertight buildings, we propose the regulation measures for the 6 m deep waterway of Liyushan channel under multiple restrictions based on the model test.