The service life of Hong Kong-Zhuhai-Macao bridge,which crosses the Pearl river estuary,is designed as 120 years.How to improve the durability of concrete structure located at the open sea with high temperature and humidity became one of the most important issues for the bridge construction.The systematical research on the concrete durability was carried out before and during the construction period based on the engineering practice.Based on the research,the strategies and measures for the durability design,construction and maintenance,which were applied to ensure the service life of 120 years,are expounded.