Wuzhou center port is close to the Xijiang river. The port has superior geographical position and convenient traffic. It is affected by the tide in the Pearl river delta downstream and by the Changzhou hydraulic complex upstream, and the hydrological and sediment conditions are complicated. Based on the analysis of Wuzhou station statistical data, and combining with the waterway regulation practice and project experience, we suggest to consider the influential factors of the low water level in port design, and give referenc value of various factors, aiming to provide reference for the port design.