In order to implement the geotechnical investigation work efficiently and with high-quality, it is necessary to write a good targeted guideline. The geotechnical engineer should not only have the profound professional knowledge, but also understand the design intent, strengthen the communication with the design, find out implied information in the design, and understand the investigation purposes comprehensively. Based on the analysis of relevant geotechnical data collected nearby and field reconnaissance, borehole position, hole depth should be reasonably arranged according to the characteristics of the engineering foundation, and the items of soil test should also be set targeted for the project. The investigation guideline in specific implementation process will vary according to the geological conditions of the site, thus specific dynamic adjustment shall be carried out accordingly, so that it will always play a guiding role in the investigation.