According to the basic principles of the bridge site selection, and combining with the bridge area project overview and channel condition, we compare the orthogonal and bias bridge sites, and draw the Jinghong Mengle bridge skew bridge site as the recommended bridge site. Based on the research on theinfluence of navigation clearance dimensions and pier bit arrangement on navigation, we determine the 330 m span steel box arch bridge as the recommended bridge. Moreover, through the flow numerical simulation and combining with the measured data, we analyze its influence on navigation flow condition and thus determine the reasonableness of the recommended scheme.