Anqing waterway has narrow inlet and outlet but very broad middle part, where develops sandbars. Through the river bed evolution analysis, the talweg now points to the middle of the river, beneficial to the middle branch development and detrimental to the navigation channel conditions. According to the development trend, waterway regulation is needed to ensure that the channel meets the standards 6.0 m×200 m×1 050 m. Firstly, the 2D flow and sediment mathematical model is utilized to simulate the effects of several different control- protection schemes, and the results indicate that submerged dike and bottom protection can limit the development of the middle branch effectively; then, on the basis of effect comparisons, comprehensive consideration is taken to propose a recommended control-protection; finally, the variation of navigation channel conditions is calculated and analyzed by water and sediment series, which can provide information for project constructions.