Navigational channel regulation parameters of the middle and lower Yangtze River are derived from the shoal regulation experience of mountain rivers or small plain rivers and are not exactly applicable for the engineering design. Based on the analysis of shoal formation causes and the summary of regulation parameters about implemented channel regulation engineering, the article discusses the adaptability of regulation parameters in the middle and lower reaches of the Yangtze River. From the basic requirement of navigational channel regulation,according to the fluvial mechanism, the article firstly proposes the concept of “regulation section”, initially put forward the connotation and calculation method of the middle and lower Yangtze River navigational channel regulation parameters, and analyzes its rationality combined with the middle and lower Yangtze River channel regulation.