The settlement of dredged fill soft clay foundation reinforced by surcharge preloading and combined vacuum-surcharge preloading is similar to three “S” type growth curves. There are many factors affecting the developing regularity of settlement in soft clay foundation, and three settlement prediction models based on growth curve reflect only one kind or several kinds of information characteristics of settlement developing regularity. The variable weight and “S” type growth curves combination model is established to analyze the settlement data of dredged fill soft clay foundation in land reclamation project by the combination of individual prediction model, the analytical results of engineering practice indicate that the future settlement by this method of variable weight and combination settlement prediction model is consistent with measures values, and compared with individual models, variable weight and combination settlement prediction model has good prediction accuracy. The model is reasonable to predict the settlement of dredged fill soft clay foundation.