According to standard methods and the engineering practice and the key technical issues of inland suspended vertical wharf with a large fluctuation, relying on a large number of numerical calculation, we make a disaster prediction for the disaster of the inland suspended vertical wharf with a large fluctuation under various load combinations. Using ArcView to combine predict results with geographic information system effectively, we establish the disaster prediction and management system of inland suspended vertical wharf with a large fluctuation, and make the dynamic management of the port security assessment. Through the assessment of the system test data, we can effectively improve the loading efficiency of the port, and make a real-time assessment of the safety performance.