Sino-Kuwait refinery/petrochemical joint venture project in Guangdong will be constructed as a super large-scale petrochemical base at Donghai island, Zhanjiang port. Due to the large construction scale of the project, a large variety of cargoes with complicated properties and extensive market to be transported by jetties, and a close relationship with large-scale steel plant and planning petrochemicals zone, many considerations have played an important role in this project. This paper analyzes and concludes relevant factors such as demonstration of construction scale for auxiliary jetties of port-related petrochemical industry, site selection of large-scale crude oil jetty, partitioning of port area, key points of general layout, etc., to determine the reasonable general layout plan of jetty engineering and provide a basis for the adjustment of existing port planning. The research conclusion of this case can be taken as a reference for similar projects.