This paper analyzes influential factors of multiple-lane lock’s joint scheduling for Changzhou hydro-junction project. Based on the lockage operating procedures, a computer simulation model is built including anchorage, channel & approach channel, parallel four-lane ship lock, ship’s joint scheduling, etc. Through the simulation experiment, this paper compares the operation effect of various scheduling plans and obtained the recommended one, which provide scientific basis for the decision-making of planning, design and management of locks.